Neximmune Inc

NexImmune, Inc. is a clinical-stage biotechnology company. The Company is engaged in developing an approach to immunotherapy designed to employ the body’s own T cells to generate an immune response that mimics natural biology. Its product candidates include NEXI-001 in acute myeloid leukemia (AML) and NEXI-002 in multiple myeloma (MM). The Company provides Artificial Immune Modulation (AIM), which is a nanoparticle technology platform. Its AIM technology enables it to construct nanoparticles that function as synthetic dendritic cells capable of directing a specific T cell-mediated immune response. The AIM nanoparticles employ signaling proteins to deliver instructions to T cells directing a desired immune response. Its T cell product candidates are designed to combine the attributes of cellular with reduced potential for toxicities. It is also developing new AIM nanoparticle constructs and modalities for clinical evaluation in oncology and in disease areas outside of oncology.

NexImmune’s precision technology and unique scientific approach offer promise in restoring hope for patients suffering from cancer and immune-mediated diseases by directing specific immune responses to target and attack those cells causing disease.
The foundation of our unique approach focuses on modulating the role that T cells play within the immune system. Our proprietary nanotechnology platform, Artificial Immune Modulation (AIM™), employs natural biology to direct specific T cell-mediated immune responses capable of treating a variety of diseases.

T cells are the “foot soldiers” of the immune system. Their role is to identify, engage, and destroy diseased cells within our bodies. Each T cell requires a specific set of instructions, otherwise the T cell is incapable of performing its critical immune function. These instructions are provided through very specific signaling proteins and are normally delivered to the T cell by dendritic cells. In many diseases, the dendritic cell becomes dysfunctional and is no longer able to direct healthy T cell function, and the immune system breaks down.

The AIM technology enables us to construct “synthetic dendritic cells,” in the form of AIM nanoparticles, which are capable of directing a specific T cell-mediated immune response. Mimicking dendritic cells, the AIM nanoparticles employ natural signaling proteins to deliver specific instructions to T cells that direct a desired immune response. Importantly, unlike other cell therapy approaches, this is accomplished without any genetic manipulation of the T cell, thereby creating T cell products that should maintain natural target identification, engagement, and killing mechanisms.