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Company Description

Ocular Therapeutix, Inc. is a biopharmaceutical company focused on the formulation, development, and commercialization of innovative therapies for diseases and conditions of the eye using its proprietary bioresorbable hydrogel-based formulation technology. Our robust product pipeline positions Ocular Therapeutix to become a leader in the ophthalmic space due to our ability to create drug delivery solutions that reduce the complexity and burden of the current standard of care by developing sustained release alternatives. With a focus on advancing our products through to Phase 3 clinical trials, our intention is to develop a commercially viable portfolio to overcome the issues of patient compliance and adherence by providing means of more consistent and reliable drug dosing for better patient outcomes.

Technology

Ocular Therapeutix hydrogel technology is a versatile platform employed to create sustained-release therapies that may expand treatment options across multiple ocular conditions. The hydrogel delivery technology enables creation of sustained release dosage forms of drugs that have been previously approved by the FDA when formulated as drops or injections. The hydrogel is a biodegradable polyethylene glycol (PEG) network and is preservative free. This hydrogel network is a meshwork that entraps the drug particles. When administered, the PEG network hydrates with water, then the drug particles begin to dissolve, diffusing the drug outward from the hydrogel into the surrounding local tissues. Following the completion of drug delivery, the hydrogel biodegrades and is cleared from the body.

Drug Pipeline

Source: Ocular Therapeutix Inc - 20221102
Asset
Indication
Phase
Dextenza
Allergic Conjunctivitis
Reg/Com
 
 
 
 
 
Postsurgical Ocular Inflammation
Reg/Com
 
 
 
 
 
OTX-CSI
Dry Eye Disease
Phase 2
 
 
 
 
 
OTX-DED
Dry Eye Disease
Phase 2
 
 
 
 
 
OTX-TIC
Glaucoma
Phase 1
 
 
 
 
 
Ocular Hypertension
Phase 1
 
 
 
 
 
OTX-TKI
Diabetic Macular Edema
Phase 1
 
 
 
 
 

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3 Comments on OCUL stock

Newest
razbiotech
about 1 year ago 𐤟 Price was $6.03

Amazing and standard setting durability for latest 10 month TKI-update in wAMD, have a listen here: https://ocutx.gcs-web.com/events/event-details/ocular-therapeutix-interim-10-month-data-update-ongoing-us-phase-1-clinical


Current marketcap is in the ~$450m range and the asset is now P3 ready. Given that KOD was trading at a mcap of ~$6b halfway through P3 studies as a "one trick pony" suggests OCUl is undervalued. I'm long. Very long. 

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razbiotech
over 1 year ago 𐤟 Price was $4.41

OCUL video #1

In this video from Eyecelerator@AAO, Peter Kaiser, MD, discusses data from a phase 1 clinical study investigating OTX-TKI for the treatment of wet age-related macular degeneration.

https://www.healio.com/news/ophthalmology/20221002/video-otxtki-shows-promising-results-in-wet-amd


OCUL video #2

Presenting author Dilsher Dhoot, MD, California Retina Consultants, discussed the analysis In an interview with HCPLive at the conference: Analysis of OTX-TKI Implant Shows Promise for Wet AMD Treatment

https://www.hcplive.com/view/dilsher-dhoot-md-analysis-otx-tki-implant-promise-wet-amd

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razbiotech
over 1 year ago 𐤟 Price was $4.09

This is fantastic data from OCUL. High dose Eylea managed 80% rescue free at 4 months in their recent P3, whereas OCUL's TKI looks like 80% rescue free at 6 months. It's still early days, but this looks like a drug to me...

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